Sahari, Aleksi; Do, Cuong Dat; Mannisto, Jere K.; Antico, Emanuele; Amaratunga, Angelo; Hopmann, Kathrin Helen; Repo, Timo (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)
We report a Ti(OiPr)4-mediated multicomponent reaction, which
produces 3,4-substituted cis-d-lactones from alkyl magnesium
chloride, benzaldehyde and CO<sub>2</sub>. The key intermediate, titanacyclopropane, is formed in situ from Ti(OiPr)4 and a Grignard reagent,
which enables 1,2-dinucleophilic reactivity that is used to insert
carbon dioxide and an aldehyde. An alternative reaction route ...